H-InvDB_8.3 released on March 26, 2013. Search by Keyword H-Inv ID (HIT) H-Inv cluster ID (HIX) H-Inv protein ID (HIP) H-Inv gene family/group (HIF) Accession number Chromosome number Chromosome band Definition* Data source ID --- CCDS ID dbSNP ID (rs number) EC number Ensembl ID EntrezGene ID FR ID FR Accession number GO ID GO name* HGNC gene symbol HGNC gene name* InterPro ID InterPro name* OMIM ID OMIM title* Pathway ID Pathway name* RefSeq (gene) ID RefSeq (protein) ID SCOP ID UniProt for Advanced Search

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H-Invitational ID: HIT000195931_05 Accession number: M60333 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: MHC cell surface glycoprotein; Major histocompatibility complex, class II, DR alpha; Precursor;

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Transcript original information Accession number M60333.1 CAGE tag ID NA EST ID NA Clone Number NA Experimental resources   NBRC ; HGPD ; Antibody (HLA-DRA) ; Catalog (HLA-DRA); Sequence data provider NA Annotation project NA Length of cDNA 744[bp] (No. of exon:4)[A:191 T:177 G:198 C:178] Devision NA Molecular type NA Library origin Cell type B-lymphoblastoid Tissue type NA Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) CAGAAG;  Transcript quality feature NA Notes NA

ACTCCCAAAAGAGCGCCCAAGAAGAAAATGGCCATAAGTGGAGTCCCTGT GCTAGGATTTTTCATCATAGCTGTGCTGATGAGCGCTCAGGAATCATGGG CTATCAAAGAAGAACATGTGATCATCCAGGCCGAGTTCTATCTGAATCCT GACCAATCAGGCGAGTTTATGTTTGACTTTGATGGTGATGAGATTTTCCA TGTGGATATGGCAAAGAAGGAGACGGTCTGGCGGCTTGAAGAATTTGGAC GATTTGCCAGCTTTGAGGCTCAAGGTGCATTGGCCAACATAGCTGTGGAC AAAGCCAACTTGGAAATCATGACAAAGCGCTCCAACTATACTCCGATCAC CAATGACAAGTTCACCCCACCAGTGGTCAATGTCACGTGGCTTCGAAATG GAAAACCTGTCACCACAGGAGTGTCAGAGACAGTCTTCCTGCCCAGGGAA GACCACCTTTTCCGCAAGTTCCACTATCTCCCCTTCCTGCCCTCAACTGA GGACGTTTACGACTGCAGGGTGGAGCACTGGGGCTTGGATGAGCCTCTTC TCAAGCACTGGGAGTTTGATGCTCCAAGCCCTCTCCCAGAGACTACAGAG AACGTGGTGTGTGCCCTGGGCCTGACTGTGGGTCTGGTGGGCATCATTAT TGGGACCATCTTCATCATCAAGGGATTGCGCAAAAGCAATGCAGCAGAAC GCAGGGGGCCTCTGTAAGGCACATGGAGGTGATGGTGTTTCTTA

Gene structure information

H-Inv cluster ID		HIX0033491
Genomic location	Chromosome	6_cox_hap2
	Location	NA
	Position	3878156- 3882154
	Strand	+
Possible duplicated location(s)		HIX0078236;
Gene structure		4 exon(s)
Database links	RefSeq	NM_019111;
	Ensembl	ENST00000383127;  ENST00000434866;  ENST00000459705;  ENST00000461633;  ENST00000462200;  ENST00000481943;  ENST00000482781;  ENST00000493431;  ENST00000498597;  ENST00000542549;
	Entrez Gene	Entrez Gene ID:3122;
	KEGG GENES	KEGG GENES(3122);
	GeneCard	HLA-DRA;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000028572 Predicted CDS 28..717;  229[aa];  Orientation:+1;  Codon Adaptation Index (CAI). 0.792 Database links RefSeq NA UniProt Q30118;  CCDS NA

MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFD FDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTK RSNYTPITNDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHY LPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLT VGLVGIIIGTIFIIKGLRKSNAAERRGPL*

Motif information

	a.a. length	InterPro	Name
	84	IPR011162	MHC classes I/II-like antigen recognition protein [Domain]
	79	IPR014745	MHC class II, alpha/beta chain, N-terminal [Domain]
	81	IPR001003	MHC class II, alpha chain, N-terminal [Domain]
	80	IPR001003	MHC class II, alpha chain, N-terminal [Domain]
	64	IPR003597	Immunoglobulin C1-set [Domain]
	87	IPR013783	Immunoglobulin-like fold [Domain]
	64	IPR003597	Immunoglobulin C1-set [Domain]
	7	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site [Conserved_site]

Gene function information

H-Inv ID		HIT000195931_05
H-Inv cluster ID		HIX0033491
Accession number		M60333.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;  Splicing isoform
Coding potential		Protein coding;
Definition		MHC cell surface glycoprotein; Major histocompatibility complex, class II, DR alpha; Precursor;
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (Q30118)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens (Human). protein.
Experimental evidence		Protein evidence
PubMed ID		2212658;  ALL;
Gene family/group	H-Inv gene family/group ID	HIF0000002
	Gene family/group name	Major histocompatibility complex (MHC).
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	HLA-DRA
	HGNC aliases	NA
	HGNC name	major histocompatibility complex, class II, DR alpha
	DDBJ	HLA-DRA
	UniProt	HLA-DRA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000028572
	No. of interaction	NA
	Interaction partner(s)	NA
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	NA
Database links	RefSeq	NM_019111;
	Ensembl	ENST00000383127;  ENST00000434866;  ENST00000459705;  ENST00000461633;  ENST00000462200;  ENST00000481943;  ENST00000482781;  ENST00000493431;  ENST00000498597;  ENST00000542549;
	Entrez Gene	Entrez Gene ID:3122;
	KEGG GENES	KEGG GENES(3122);
	GeneCard	HLA-DRA;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Biological process	antigen processing and presentation (GO:0019882);  immune response (GO:0006955);
Cellular component	membrane (GO:0016020);  MHC class II protein complex (GO:0042613);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	extracellular;  endoplasmic;
Target P	signal peptide
SOSUI	membrane protein
TMHMM	membrane protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.