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H-Invitational ID: HIT000021733 Accession number: AK096878 Created date: 26-Mar-2013 Last modified: 20-Apr-2012 Definition: Transcription cofactor vestigial-like protein 2 isoform 1.

		Select format Flat file XML file Nucleotide sequence fasta Protein sequence fasta

Transcript original information Accession number AK096878.1 CAGE tag ID NA EST ID NA Clone Number SKMUS2000701 Experimental resources   NBRC ; HGPD ; Antibody (VGLL2) ; Catalog (VGLL2); Sequence data provider Project:FLJ; Provider:FLJ/HRI;  Annotation project H-Invitational FLcDNA Length of cDNA 1161[bp] (No. of exon:4)[A:215 T:191 G:314 C:441] Devision HUM Molecular type mRNA Library origin Cell type NA Tissue type skeletal muscle Develpmental stage NA

Sequence quality information CDS feature Complete CDS Kozak sequence NA PolyA NA Vector/adapter sequence NA Frame shift NA Remaining intron NA Splice site acceptor (NAGNAG) NA Transcript quality feature NA Notes NA

AACCGTCTCCGCTGCGGAGAGTCATGAGCTGTCTGGATGTTATGTACCAA GTCTATGGTCCTCCGCAGCCCTACTTCGCAGCCGCCTACACCCCCTACCA CCAGAAACTAGCCTATTATTCCAAAATGCAGGAAGCGCAGGAGTGCAATG CCAGCCCCAGCAGCAGTGGCAGCGGCAGCTCCTCATTTTCCAGCCAAACC CCAGCCAGTATAAAAGAGGAAGAAGGCAGCCCAGAGAAAGAGCGCCCACC AGAGGCAGAGTACATCAACTCCCGCTGCGTCCTCTTCACTTATTTCCAGG GGGACATCAGCTCCGTGGTGGATGAACATTTCAGCAGGGCCCTGAGCCAA CCCAGCAGCTACTCTCCTAGCTGTACCAGCAGCAAAGCACCAAGGAGCTC TGGGCCCTGGCGAGACTGCTCCTTCCCGATGAGCCAGCGCAGCTTCCCCG CCTCCTTCTGGAATAGCGCGTACCAGGCGCCAGTGCCCCCGCCGCTGGGC AGCCCTCTGGCCACCGCGCACTCGGAGCTGCCCTTCGCCGCCGCCGACCC CTACTCGCCCGCCGCGCTGCATGGCCACCTGCACCAGGGCGCCACGGAGC CCTGGCACCACGCGCACCCGCACCACGCGCACCCGCATCACCCCTACGCC CTGGGCGGCGCCCTCGGCGCCCAGGCCGCCCCCTACCCGCGCCCCGCCGC CGTGCACGAAGTCTACGCGCCGCACTTCGACCCGCGCTATGGGCCGCTGC TGATGCCAGCCGCCTCGGGGCGCCCGGCCCGCCTCGCAACCGCCCCGGCG CCCGCGCCCGGCAGTCCTCCCTGCGAGCTCTCCGGCAAAGGCGAGCCGGC GGGCGCCGCGTGGGCCGGGCCCGGGGGACCCTTCGCGAGCCCCTCGGGGG ACGTGGCCCAGGGTCTGGGCCTCAGCGTGGACTCAGCTCGTCGTTATTCC CTCTGTGGTGCATCCCTCCTGAGCTGATCTGCTGACCCAGGGTTTCCCCT TCCCCTTCCCTTCTGACCAGCCTTGGAGGCTCAGCATCTGTGCCTCTCAC TCCGTGGATGAGGACATGGGGGAAGGCAGAGACTTCAGACTTCTCAGTGT GTTGGGAAAACCAAAAACCACAACTACAGAAATTCATCTAAATAAAAGTT CTATGATCTGC

Gene structure information

H-Inv cluster ID		HIX0006170
Genomic location	Chromosome	6
	Location	6q22.1
	Position	117586904- 117593832
	Strand	+
Possible duplicated location(s)		NA
Gene structure		4 exon(s)
Database links	RefSeq	NM_153453;  NM_182645;
	Ensembl	ENST00000326274;  ENST00000352536;
	Entrez Gene	Entrez Gene ID:245806;
	KEGG GENES	KEGG GENES(245806);
	GeneCard	VGLL2;  *GeneCards is provided free to academic non-profit institutions.
Related H-InvDB links		H-DBAS;  G-integra;  cDNA-genome alignment;

Predicted CDS information HIP ID HIP000096250 Predicted CDS 24..977;  317[aa];  Orientation:+3;  Codon Adaptation Index (CAI). 0.786 Database links RefSeq NP_872586;  UniProt Q8N8G2;  CCDS CCDS5115;

MSCLDVMYQVYGPPQPYFAAAYTPYHQKLAYYSKMQEAQECNASPSSSGS GSSSFSSQTPASIKEEEGSPEKERPPEAEYINSRCVLFTYFQGDISSVVD EHFSRALSQPSSYSPSCTSSKAPRSSGPWRDCSFPMSQRSFPASFWNSAY QAPVPPPLGSPLATAHSELPFAAADPYSPAALHGHLHQGATEPWHHAHPH HAHPHHPYALGGALGAQAAPYPRPAAVHEVYAPHFDPRYGPLLMPAASGR PARLATAPAPAPGSPPCELSGKGEPAGAAWAGPGGPFASPSGDVAQGLGL SVDSARRYSLCGASLLS*

Motif information

	a.a. length	InterPro	Name
	33	IPR011520	Vestigial/tondu [Family]

Gene function information

H-Inv ID		HIT000021733
H-Inv cluster ID		HIX0006170
Accession number		AK096878.1
CAGE tag ID		NA
EST ID		NA
Transcript feature		NO;
Coding potential		Protein coding;
Definition		Transcription cofactor vestigial-like protein 2 isoform 1.
Similarity category		Category: Identical to known human protein(Category I).
		Identical to known human protein (NP_872586)  [Identity/coverage = 100.0%/100.0%] to Homo sapiens protein.
Experimental evidence		Protein evidence
PubMed ID		NA
Gene family/group	H-Inv gene family/group ID	NA
	Gene family/group name	NA
	Evidence motif (InterPro) ID	NA
Gene symbol/name	HGNC symbol	VGLL2
	HGNC aliases	NA
	HGNC name	vestigial like 2 (Drosophila)
	DDBJ	NA
	UniProt	NA
EC number		NA
GGDB (GlycoGene Database)	Gene symbol	NA
	Familly	NA
	Designation	NA
	Expression	NA
KEGG metabolic pathway		NA
Protein-protein interaction (PPI)	H-Inv protein ID	HIP000096250
	No. of interaction	1
	Interaction partner(s)	HIP000360727;
	BIND	NA
	DIP	NA
	MINT	NA
	HPRD	NA
	IntAct	EBI-1609906;
Database links	RefSeq	NM_153453;  NM_182645;
	Ensembl	ENST00000326274;  ENST00000352536;
	Entrez Gene	Entrez Gene ID:245806;
	KEGG GENES	KEGG GENES(245806);
	GeneCard	VGLL2;  *GeneCards is provided free to academic non-profit institutions.
	etc	Human-Gene diversity Of Life-style related Diseases;
Curation status		Auto-annotated
Notes		NA
Related H-InvDB links		Gene family;  Similarity Search Tool;  TACT;

fRNAdb (The functional RNA database) : overlapping fRNAdb entries with H-InvDB transcripts based on the location of the genome.

NA

Gene ontology information

Molecular function	transcription regulator activity (GO:0030528);
Biological process	regulation of transcription (GO:0045449);
Cellular component	nucleus (GO:0005634);

Subcellular localization information

Last modified:20-Apr-2012

WoLF PSORT	nuclear;  cytosol;
Target P	Other
SOSUI	soluble protein
TMHMM	soluble protein
PTS1	Not targeted
Related H-InvDB links	LIFEdb;  JRE-1.4.0 or later is required. Download JRE at Sun's web site.

Gene expression information

Last modified:20-Apr-2012

Tissue-specific expression			NA
Probe information	AceGene		NA
	Affymetrix GeneChip	HG-Focus	NA
		HG-U133	NA
		HG-U133A	NA
		HG-U133A_2	NA
		HG-U133B	NA
		HG-U133_Plus_2	NA
		HG-U95	NA
		HG-U95A	NA
		HG-U95B	NA
		HG-U95C	NA
		HG-U95D	NA
		HG-U95E	NA
		HG-U95Av2	NA
		HuEx-1_0	2922942;  2922943;  2922947;  2922951;  2922952;  2971258;
		HuGeneFL	NA
	Agilent	Human 1A Oligo Microarray:PGID215	NA
		Whole Human Genome Oligo Microarray:PGID247	A_32_P459849;
Related H-InvDB links			H-ANGEL;  DNAProbeLocator;

Disease/pathology information

Last modified:20-Apr-2012

Disease relation		Disease name:NA
Related information in OMIM		OMIM ID:NA Title:NA
Co-localized orphan diseases		OMIM ID:  122550;  143400;  604519;  608545;  610294;  611724;  612558;
Disease related mutation		NA
Literature-Extracted GENe-Disease Associations (LEGENDA)	Gene name	Entrez Gene ID:(245806)
	Disease	Entrez Gene ID:(245806)
	Substance	Entrez Gene ID:(245806)
Related H-InvDB links		DiseaseInfo Viewer;  LEGENDA;

Polymorphism (SNP, indel), microsatellite (Short Tandem Repeat, STR) and repeat information

Single Nucleotide Polymorphism (SNP) and indel  Location Variation dbSNP ID Strand CDS/UTR Translation 122 .. 122 C/A rs61746898 + CDS Synonymous[Ser33Ser] 185 .. 185 A/C rs79582565 + CDS Synonymous[Ser54Ser] 250 .. 250 C/A rs41291916 + CDS Nonsynonymous[Pro76Gln] 278 .. 278 C/T rs35052255 - CDS Synonymous[Cys85Cys] 464 .. 464 T/C rs13194610 + CDS Synonymous[Asn147Asn] 1112 .. 1112 C/A rs76963111 + 3'UTR  Microsatellite (Short Tandem Repeat, STR) No data available  Microsatellite: Human-Gene diversity Of Life-style related Diseases (H-GOLD) No data available

Repeat  No data available Database links Human-Gene diversity Of Life-style related Diseases(H-GOLD);  Related H-InvDB links VaryGene;  Repeat Mask Viewer;