HIX0021591 HIX0021591.15 HIT000000001 HIT000000001.15 AB002292 AB002292.2 build 37.1 HUM mRNA 14-Feb-2004 16-Feb-2010 16-Feb-2010 7.0 7.0 16-Feb-2010 16-Feb-2010 7.0 8 8p23.3 1772142 1906799 + 534 135191 9639 ENST00000262112 ENST00000349830 ENST00000382794 ENST00000382795 ENST00000398560 ENST00000398564 9639 NM_014629 Representative transcript Representative transcript Splicing isoform CAGAAG CAGCAG CAGGAG HIP000042367 HIP000042367.1 NP_055444 A8MS93 15103394 hf00223s1 brain KDRI 5589 29 1495 1244 1467 1383 16-Feb-2010 16-Feb-2010 7.0 608236 Slowed nerve conduction velocity, AD 608136 RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10 148370 606129 606662 609259 612279 16-Feb-2010 16-Feb-2010 7.0 AK147669 Mus musculus (Mouse) MGI:3573648 CR391701 Gallus gallus (Chicken) ENSBTAT00000011324 Bos taurus (Cow) ENSORLT00000021592 Oryzias latipes (Medaka) ENSPPYT00000021326 Pongo sp. (Orangutan) ENSRNOT00000016745 Rattus norvegicus (Rat) SINFRUT00000172682 Takifugu rubripes (Fugu) XM_001381452 Monodelphis domestica (Opossum) XM_001916790 Equus caballus (Horse) XM_001921405 Danio rerio (Zebrafish) XM_528056 Pan troglodytes (Chimpanzee) XM_528056 Pan troglodytes (Chimpanzee) XM_680636 Danio rerio (Zebrafish) XM_846774 Canis familiaris (Dog) XR_014797 Macaca sp. (Macaque) 40 40 .. rs71518092 G/A 5'UTR + 50 50 .. rs71518093 A/G 5'UTR + 325 325 .. rs4875950 A/C CDS Synonymous[Pro47Pro] - 571 571 .. rs749822 A/G CDS Synonymous[Val129Val] + 775 775 .. rs2272708 C/T CDS Synonymous[Ala197Ala] + 814 814 .. rs7003969 G/A CDS Synonymous[Glu210Glu] + 1179 1179 .. rs28940281 C/T CDS Nonsynonymous[Thr332Ile] + 1294 1294 .. rs9657362 G/C CDS Nonsynonymous[Leu370Phe] + 1297 1297 .. rs34655804 C/T CDS Synonymous[Phe371Phe] + 1615 1615 .. rs3758004 C/T CDS Synonymous[Phe477Phe] + 1831 1831 .. rs12681485 C/T CDS Synonymous[Leu549Leu] + 1938 1938 .. rs1045489 G/A CDS Nonsynonymous[Arg585Lys] + 2175 2175 .. rs34319003 T/C CDS Nonsynonymous[Met664Thr] + 2239 2239 .. rs2294038 T/C CDS Synonymous[Tyr685Tyr] + 2282 2282 .. rs2294039 G/A CDS Nonsynonymous[Val700Ile] + 2287 2287 .. rs2294040 C/T CDS Synonymous[His701His] + 2320 2320 .. rs61731549 G/A CDS Synonymous[Ala712Ala] + 2569 2569 .. rs34036746 C/T CDS Synonymous[Asp795Asp] + 2644 2644 .. rs61758704 C/G CDS Nonsynonymous[Asn820Lys] + 2764 2764 .. rs2272613 C/T CDS Synonymous[Pro860Pro] - 2920 2920 .. rs2272611 C/T CDS Synonymous[Ile912Ile] - 2939 2939 .. rs35354057 A/C CDS Nonsynonymous[Thr919Pro] + 2996 2996 .. rs61752020 G/A CDS Nonsynonymous[Val938Ile] + 3093 3093 .. rs35925274 C/T CDS Nonsynonymous[Thr970Met] + 3134 3134 .. rs17683288 T/G CDS Nonsynonymous[Ser984Ala] + 3200 3200 .. rs2272610 A/T CDS Nonsynonymous[Thr1006Ser] - 3232 3233 ^ rs35849152 -/G CDS + 3403 3403 .. rs61758705 A/G CDS Synonymous[Val1073Val] + 3598 3598 .. rs2272609 G/A CDS Synonymous[Ser1138Ser] - 3622 3622 .. rs2272608 C/T CDS Synonymous[His1146His] - 3703 3703 .. rs61731551 C/T CDS Synonymous[Thr1173Thr] + 3922 3922 .. rs3735876 G/A CDS Synonymous[Ser1246Ser] + 4157 4157 .. rs35095003 C/T CDS Nonsynonymous[Pro1325Ser] + 4518 4518 .. rs6558566 A/G 3'UTR + 4613 4613 .. rs6991392 A/G 3'UTR + 4844 4844 .. rs60260705 G/A 3'UTR + 5420 5420 .. rs14375 T/G 3'UTR + 5499 5499 .. rs11986753 T/C 3'UTR + 1 137 138 221 222 377 378 665 666 729 730 806 807 863 864 1027 1028 1144 1145 1259 1260 1366 1367 1444 1445 1624 1625 1741 1742 1834 1835 2005 2006 2151 2152 2327 2328 2443 2444 2571 2572 2672 2673 2794 2795 2881 2882 3105 3106 3263 3264 3406 3407 3581 3582 3704 3705 5589 1772142 1772279 1791519 1791602 1806126 1806281 1808063 1808350 1812539 1812602 1814692 1814768 1817360 1817416 1824737 1824900 1828214 1828330 1830801 1830915 1833767 1833873 1841735 1841812 1842559 1842738 1844499 1844615 1846599 1846691 1851447 1851617 1853737 1853882 1857461 1857636 1871130 1871245 1871634 1871761 1871940 1872040 1873449 1873570 1874543 1874629 1876593 1876816 1877452 1877609 1881966 1882108 1893647 1893821 1900871 1900993 1904915 1906799 1791566 1905429 GGGGTCGCGGGGGACGCGGGGGACGCGGGGGACGCGGGGGACGGCGGGGAACGGCGGGGAACAGCGGGGGACGGCGGGGAACAGCGGGGGACGGCGGGGAACAGCAGGGGACTGCGGGTCGCGTCCTGGCCGCCGAGGAGCTCCTTCCCTTAACAGAGCTGAGAGAGGCATCTGGAGCTGCAGCATGGACCAGCGAGAGCCCCTGCCTCCCGCTCCTGCAGAAAATGAAATGAAATATGATACCAATAATAATGAAGAGGAAGAGGGAGAACAGTTCGATTTTGACAGTGGAGATGAAATCCCAGAAGCGGACAGACAGGCCCCATCCGCCCCTGAGACAGGAGGTGCTGGAGCCAGTGAAGCCCCTGCACCCACAGGAGGTGAGGATGGAGCTGGAGCAGAAACCACCCCAGTGGCAGAGCCTACTAAGCTGGTGCTCCCGATGAAAGTCAACCCATATTCTGTCATCGACATCACGCCATTCCAGGAGGACCAGCCGCCCACCCCCGTGCCCAGCGCTGAGGAGGAGAATGTGGGTCTCCATGTGCCCTGCGGGTACTTGGTGCCTGTACCCTGCGGCTATGCGGTGCCCTCCAACCTGCCCCTCCTGCTGCCCGCCTACTCCAGCCCGGTCATCATCTGCGCCACGTCCCTGGACGAAGAAGAAACACCAGAAGTCACAGAAGATCGCCAGCCCAATTCTCTGAGTTCCGAGGAGCCTCCAACCAGTGAAGATCAAGTCGGTCGAGAGGACAGCGCACTTGCCCGCTGGGCCGCAGACCCGGCCAACACAGCCTGGATGGAGAATCCAGAGGAAGCAATTTACGATGACGTTCCAAGGGAAAACTCAGACTCTGAACCAGATGAAATGATTTATGATGATGTTGAGAATGGGGATGAAGGTGGAAACAGCTCCTTGGAATACGGATGGAGTTCGAGTGAATTTGAAAGTTACGAAGAGCAGAGTGACTCGGAGTGCAAGAATGGGATTCCCAGGTCCTTCCTGCGCAGCAACCACAAAAAGCAACTTTCTCATGACCTAACCCGTTTAAAGGAGCACTATGAGAAAAAGATGAGAGATTTGATGGCAAGCACGGTGGGCGTGGTGGAGATTCAGCAGCTCAGGCAGAAGCATGAACTGAAGATGCAGAAGCTCGTGAAGGCCGCGAAGGACGGCACCAAGGACGGGCTGGAGAGGACCAGGGCAGCCGTGAAGAGGGGCCGCTCCTTCATCAGGACCAAGTCTCTCATCGCACAGGATCACAGATCTTCTCTTGAGGAAGAACAGAATTTGTTCATTGATGTTGACTGCAAGCACCCGGAAGCCATCTTGACCCCGATGCCCGAGGGTTTATCTCAGCAGCAGGTTGTAAGAAGATATATACTGGGTTCAGTTGTCGACAGTGAAAAGAACTACGTAGATGCTCTTAAGAGGATTTTGGAGCAATATGAGAAGCCGCTGTCTGAGATGGAGCCAAAGGTTCTGAGTGAGAGGAAGCTGAAGACGGTGTTCTACCGAGTCAAAGAGATCCTGCAGTGCCACTCGCTATTTCAGATCGCGCTGGCCAGCCGCGTTTCCGAGTGGGACTCCGTGGAAATGATAGGCGATGTCTTCGTGGCTTCGTTTTCTAAGTCCATGGTGCTGGATGCATACAGTGAATATGTGAACAATTTCAGCACAGCCGTGGCAGTCCTCAAGAAAACATGTGCCACAAAGCCCGCTTTTCTTGAATTTTTAAAGCAGGAACAGGAGGCCAGCCCCGATCGAACCACGCTCTACAGCCTGATGATGAAGCCCATCCAGAGGTTCCCACAGTTCATCCTCCTGCTCCAGGACATGCTGAAGAACACCTCCAAAGGCCACCCCGACAGGCTGCCTCTTCAGATGGCCCTGACAGAGCTCGAAACACTAGCAGAGAAGTTAAATGAAAGAAAGAGAGATGCTGATCAACGCTGTGAAGTGAAGCAAATAGCCAAAGCCATAAACGAAAGATACCTGAACAAGCTTCTCAGCAGTGGAAGCCGATACCTCATTCGATCAGATGATATGATAGAAACAGTTTACAACGACAGAGGAGAGATTGTTAAAACCAAAGAACGCCGAGTCTTCATGTTAAATGATGTGTTAATGTGTGCCACCGTCAGCTCACGCCCCTCTCATGACAGCCGTGTGATGAGCAGCCAGAGGTACTTGCTGAAGTGGAGCGTTCCACTGGGACATGTGGACGCCATCGAGTATGGCAGCAGCGCAGGCACGGGCGAGCACAGCAGGCACCTTGCCGTTCACCCGCCGGAGAGCCTGGCCGTGGTTGCTAACGCGAAACCAAACAAAGTTTACATGGGGCCAGGACAACTGTATCAAGATTTACAAAACTTGTTGCATGACTTAAATGTAATTGGCCAAATCACTCAGCTGATAGGAAACCTTAAAGGAAACTATCAGAACTTAAACCAGTCAGTAGCCCATGACTGGACATCAGGTTTACAAAGGCTTATTTTGAAGAAAGAAGATGAAATCAGAGCTGCGGACTGCTGCAGAATTCAGTTACAGCTTCCCGGGAAGCAGGACAAATCTGGGCGACCGACGTTCTTTACAGCTGTGTTCAATACGTTCACCCCTGCCATCAAGGAGTCCTGGGTCAACAGCTTACAGATGGCCAAGCTCGCCCTAGAAGAGGAGAACCACATGGGCTGGTTCTGTGTGGAAGACGATGGGAATCACATTAAAAAGGAGAAGCATCCTCTCCTCGTCGGACACATGCCCGTGATGGTGGCCAAGCAGCAGGAGTTCAAGATTGAATGTGCTGCTTATAACCCTGAACCTTACCTAAATAATGAAAGCCAGCCAGATTCATTTTCCACGGCACATGGTTTCCTGTGGATCGGAAGTTGCACCCATCAAATGGGTCAGATTGCCATCGTCTCGTTTCAAAATTCCACTCCCAAAGTCATTGAGTGCTTCAACGTGGAATCTCGCATCCTGTGCATGCTGTACGTTCCCGTCGAGGAGAAGCGCAGAGAGCCTGGGGCACCCCCGGACCCCGAGACCCCGGCCGTGAGAGCTTCTGATGTCCCCACGATCTGTGTAGGGACGGAGGAGGGAAGCATTTCCATTTATAAAAGCAGTCAAGGCTCCAAGAAAGTGAGACTTCAGCACTTTTTCACTCCTGAGAAGTCCACAGTCATGAGCCTGGCTTGCACGTCTCAGAGCCTGTACGCTGGCCTGGTCAACGGGGCAGTCGCCAGCTACGCCAGAGCCCCAGATGGATCCTGGGATTCAGAACCTCAAAAAGTGATCAAGTTAGGCGTCCTACCAGTTAGAAGTCTACTCATGATGGAAGACACGTTGTGGGCGGCTTCCGGAGGTCAAGTCTTCATCATCAGTGTGGAGACTCATGCTGTAGAGGGTCAGCTGGAGGCCCACCAGGAGGAAGGCATGGTGATCTCCCACATGGCCGTGTCCGGCGTCGGGATCTGGATTGCCTTCACCTCAGGGTCCACGCTCCGCCTTTTTCACACGGAAACTCTCAAGCACCTGCAGGACATCAACATCGCCACCCCTGTTCACAACATGCTGCCAGGGCACCAGCGGCTGTCGGTGACGAGCCTGCTCGTCTGCCACGGATTGCTGATGGTCGGCACCAGCCTGGGAGTCCTCGTGGCCCTGCCGGTCCCACGTCTGCAAGGGATTCCCAAAGTGACCGGAAGAGGCATGGTCTCCTACCATGCACACAACAGTCCTGTCAAATTCATCGTCCTGGCCACGGCTCTGCACGAGAAAGACAAGGACAAATCCAGGGACAGCCTGGCTCCTGGCCCCGAGCCTCAGGACGAAGACCAGAAGGACGCACTTCCGAGTGGAGGAGCTGGTTCATCTCTGAGCCAGGGTGACCCTGACGCAGCCATCTGGTTGGGAGATTCGCTGGGATCGATGACTCAGAAAAGCGACCTGTCCTCCTCATCTGGGTCCCTGAGCTTGTCTCACGGCTCCAGCTCTCTAGAGCACAGATCAGAGGACAGCACCATCTATGATCTCCTGAAGGATCCTGTCTCGCTGAGAAGCAAAGCACGCCGGGCCAAGAAAGCCAAGGCCAGCTCGGCGCTGGTGGTCTGTGGAGGGCAGGGCCACCGCCGGGTGCACAGGAAGGCCCGGCAGCCCCACCAGGAAGAGCTGGCGCCGACCGTCATGGTCTGGCAGATCCCTCTGCTGAATATATAAGCAGGACGGCCGCCTTCTGCTGTCAGAATTTGCAATCAAGGGTGACTTCTCAGCTAATCCTACAGCCTGAGTGGTTAAGCTGTGTCTACACTGGTTGGGAATAAATTAAAAACAGTATTTGGGGGAGAAACGTGCAATAGCGTAATGGTGGTGTCCCTGCCAATTCCTTCCTTCTCTTCTGTACAGCAGAAGTAATTACAAGCACTTCTCACGAAGGCAGAAGACTGATGCAATTTTCGAGTAATTGAGTGCAGTTCTGGGAAAATACCACATTCTTTTTGACTGCTGTAGTCCATATATGAATACTAAATGTTAAACTTCATCAGCGTCAGACCTATTGTATCATATTAGAGAATTTGCAGACTAAGAATTTATGAGAAAATATATGTATTCAGTAGTGCAGGCATTTATTAACAATTCTTAAAAGTTTTACCTGATTCAGATTCACGACTTTTATTTATATTCTATATTTTTGAATTTCAGAGTAAAATTTGTTAACAATTTTAAAAGCCAGGTAACACCTACCAGTCCAGTTAGCATGATTTGCTTTCAGAAGTGAGCTGGGTTTTCCAAAGTGGTATAATGTGTGTACTGTATATTTTAACAAAGTAATATTTTTGTATTGCATTTTTCTATTAAAAAATTAACAGTTAATGTTTCAGTCAATGTATTATCTGTAGCATTTCACAAATAATGTTTGCTTTGAACCAAAATGCTCAGTGCCTATCAACATTTGGACTCAAGCATCAACACCAAATTATTCCTCCCTTCTCGTATAAATAGAGTGACTATCCACAGGAGAAAAGTGTGTGCTTTAGTATTAGAGGAGATAGGCAGAGAAGTCTTGCTTAGTTCCTTCGTGCAGCTTCTTGCCCCTGTTGACGTGGAATGCTGTGTCTGCTTTAGCACGCACGCTCCGAATGACTCCTGGTGCTAGGCCATGCTGGCTGCTGTCACTGAGCGGGACTCAGGCCAAGAGGCGTGACCTCGGGCCAGCCTGTCTGTTGTGCAGACGCCTCCTCTGCAGAACGCATCAGTTTCTATTCTGCAGTTGCAGAGCCAGCCCCGCGTGAGAACGTGCATAATGAGTGCACACCATCATGTCAAGGTGCATACTTAGTGAGCGCCATCCTGCTGAACGTGTATTTCAGTGTTTCACTTACTGGACGGATAACAAGAAAAAAATCCTAACACAGGCAGTCACCAGAAATAAATGTCTCAGCACTTTACAGATGACTAAAAATGTTAATTTTATGACTTAGCCAAATATGTTCTAGGTTGCATATATCCCCCATGTGAAAGTGATTTCTTCCCAAGCTTCTCAAACTGTTAGCTGCTGTCTGACTTCATCAATAAAGTATTTTTATTTT Protein coding 1 5589 185 4219 1344 forward +2 Complete CDS 0.769 NP_055444 100.0 100.0 Homo sapiens Human curated Rho guanine nucleotide exchange factor 10. Identical to known human protein(Category I). Protein evidence 1 KIAA0294 ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 Human gene family/group candidate, HIF0003868. HIF0003868 IPR000219 Dbl homology (DH) domain Domain 1334 1981 1346 1942 1370 1933 1382 1930 Molecular function 0005089 Rho guanyl-nucleotide exchange factor activity Cellular component 0005622 intracellular Biological process 0035023 regulation of Rho protein signal transduction IPR011046 WD40 repeat-like Domain 2987 3646 16-Feb-2010 16-Feb-2010 7.0 cytosol nuclear mitochondria plasma membrane Other Other membrane protein soluble protein TVMVWQIPLLNI -27.831 Not targeted 16-Feb-2010 16-Feb-2010 7.0 388 596 1ki1B1 1e-37 27.0 204/210 a.87.1.1 YES MDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADRQAPSAPETGGAGASEAPAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVIDITPFQEDQPPTPVPSAEEENVGLHVPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATSLDEEETPEVTEDRQPNSLSSEEPPTSEDQVGREDSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDEGGNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDLMASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDHRSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWIGSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGAPPDPETPAVRASDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVASYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVTSLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKDKDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSSGSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHRKARQPHQEELAPTVMVWQIPLLNI* 16-Feb-2010 16-Feb-2010 AceGene AceGene AGhsA061219 Affymetrix GeneChip HG-Focus 216620_s_at HG-U133 216620_s_at HG-U133A 216620_s_at HG-U133A_2 216620_s_at HG-U133_Plus_2 216620_s_at HG-U95 34180_at HG-U95A 34180_at HG_U95Av2 34180_at HuEx-1_0 3082875 3082877 3082878 3082882 3082883 3082886 3082887 3082888 3082892 3082899 3082900 3082901 3082902 3082903 3082904 3082908 3082909 3082910 3082917 3082919 3082926 3082927 3082928 3082929 3082930 3082932 3082936 3082937 3082940 3082944 3082948 3082950 3082951 3121542 3121578 3121579 Agilent probe set Human 1A Oligo Microarray:PGID215 A_23_P216282 Whole Human Genome Oligo Microarray:PGID247 A_23_P216282 A_24_P283535