Evola  Search ortholog by   Keyword   (Human) Accession number   (All species) Gene symbol   (Human)              (  All species Chimpanzee Macaque Mouse Rat Dog Horse Cow Opossum Chicken Zebrafish Medaka Tetraodon Fugu with   All annotation status Manual curation  )

[ Japanese ]

↑ Example: lung cancer (Keyword), AB002303, ENST00000338008, NM_173392 (Accession number), RHEB (Gene symbol)

What is Evola? Evola (http://www.h-invitational.jp/evola/) contains ortholog information of all human genes among vertebrates. Orthologs are a pair of genes in different species that evolved from a common ancestral gene by speciation. In Evola, orthologs were detected by comparative genomics and amino acid sequence analysis (Computational analysis). Based of phylogenetic tree analysis, orthologs for which the same phylogenetic relationships were estimated in genes and species are provided, too (Manual curation). Evola also features comparison of orthologs and paralogs (a pair of genes that evolved by duplication) in each gene family between human and other species. [ Sample1, Sample2 ]     Evola is available for free of charge. Please cite this publication, if you use Evola.     Matsuya A, Sakate R, Kawahara Y, et al. Nucleic Acids Res. 2008; 36: D787-92.

What's New [16-Oct-2009] A bug that phylogenetic tree viewer (ATV) may erroneously show a previously selected tree was fixed. [11-Aug-2009] Help pages were updated. [27-Apr-2009] Erroneous paralog flags (_) of RefSeq XR in alignments and trees were corrected. [30-Mar-2009] Evola release 6.0: Four species were updated (Mouse, Cow, Horse, Zebrafish). Orthologs of alternative splicing variants were newly available. [30-Sep-2008] All data in the download page were completely updated to Evola release 5.1. [30-Apr-2008] Evola release 5.1: Program bug fix and related ortholog data correction were conducted. [26-Dec-2007] Evola release 5.0: Horse and Medaka were added. Duplicate gene family viewer was released. [27-Sep-2007] Annotation status (Manual curation) and NJ/NJML+ trees were updated. [27-Jun-2007] Evola release 4.1: Ortholog data were updated by a modified detection method. [24-May-2007] dN/dS view was renewed. [30-Mar-2007] Evola release 4.0: Addition of species and new ortholog data supported by computational analysis were available. [28-Sep-2006] Evola release 3.1: Orthologs were classified into manually curated ones and computationally analyzed ones. [23-Jun-2006] Evola release 2.1: Ortholog data were updated due to the update of human representative transcripts in H-InvDB 3.4. [19-May-2006] NJML+ trees were added. [31-Mar-2006] Evola release 2.0: New ortholog data supported by computational analysis were available. [31-Aug-2005] Evola was released.

Evola 6.0 Statistics Species Genes* Human genes* Human  hg18 22,496 - Chimpanzee  panTro2 19,442 19,663 Macaque  rheMac2 17,507 17,739 Mouse  mm9 17,540 17,831 Rat  rn4 16,110 16,453 Species Genes* Human genes* Dog  canFam2 16,588 17,006 Horse  equCab1 15,998 16,359 Cow  bosTau4 15,348 15,642 Opossum  monDom4 12,083 12,342 Chicken  galGal3 11,567 12,112 Species Genes* Human genes* Zebrafish  danRer5 14,165 13,262 Medaka  oryLat1 12,683 12,359 Tetraodon  tetNig1 11,807 11,575 Fugu  fr2 12,710 12,455

* Numbers of "Genes" and "Human genes" are usually different because, besides one-to-one orthologs, one-to-many or many-to-many orthologs may exist.

Hedges and Kumar 2002 (modified)

Evola was constructed and maintained by Ryuichi Sakate, Ph.D., at IDB.

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Related sites - G-compass: Comparative genome browser